When two American girls on a bike trip in a remote part of Argentina split up and one of them goes missing, the other must find her before her worst fears are realized.

Ten years have passed since Dr. Hannibal Lecter escaped from custody, ten years since FBI Agent Agent Clarice Starling interviewed him in a maximum security hospital for the criminally insane. The doctor is now at large in Europe, pursuing his own interests and savoring the scents and essences of an unguarded world. But Starling has never forgotten her encounters with Dr. Lecter, and the metallic rasp of his seldom-used voice still haunts her dreams. But Mason Verger remembers Dr. Lecter, too, and is obsessed with revenge. Verger was Dr. Lecter's sixth victim, and though hideously disfigured, has survived to rule a vast financial empire. Verger soon realizes that in order to draw the doctor out into the open, he must use someone Lecter cannot resist as bait: Clarice Starling.

As a deadly battle rages over Jigsaw's brutal legacy, a group of Jigsaw survivors gathers to seek the support of self-help guru and fellow survivor Bobby Dagen, a man whose own dark secrets unleash a new wave of terror.

Explores the origins of the centuries-old blood feud between the aristocratic vampires known as Death Dealers and their onetime slaves, the Lycans.