A woman who lives in a darkened old house with her two photosensitive children becomes convinced that her family home is haunted.

Toward the end of World War II, Russian soldiers pushing into eastern Germany stumble across a secret Nazi lab, one that has unearthed and begun experimenting with the journal of one Dr. Victor Frankenstein. The scientists have used the legendary Frankenstein's work to assemble an army of super-soldiers stitched together from the body parts of their fallen comrades -- a desperate Hitler's last ghastly ploy to escape defeat.

A young doctor in a US hospital administers a powerful and untested cocktail of drugs to a coma victim. But instead of curing him, it triggers a powerful "out-of-body" experience and enables the patient - a depraved and dangerous loner - to inhabit other people's bodies and, through them, take revenge on the bullying medical students who were accidentally responsible for his condition. The doctor, who was herself a part of this group, is also targeted and as her colleagues are singled out and relentlessly picked off, she realises that she can trust no-one - friend or stranger - as this comatose killer moves in and out of bodies at will, getting ever closer as his murderous supernatural powers increase.

Ex-FBI agent Will Graham is an expert investigator who quit the Bureau after almost losing his life in the process of capturing the elusive Dr. Hannibal Lecter. Years later, after a series of particularly grisly murders, Graham reluctantly agrees to come out of retirement and assist in the mysterious case. But he soon realizes that the best way to catch this killer, known as the Tooth Fairy, is to find a way to get inside the killer's mind. And the closest thing to that would be to probe the mind of another killer who is equally brilliant and twisted. For Graham, that means confronting his past and facing his former nemesis, the now-incarcerated Dr. Lecter.