Ex-FBI agent Will Graham is an expert investigator who quit the Bureau after almost losing his life in the process of capturing the elusive Dr. Hannibal Lecter. Years later, after a series of particularly grisly murders, Graham reluctantly agrees to come out of retirement and assist in the mysterious case. But he soon realizes that the best way to catch this killer, known as the Tooth Fairy, is to find a way to get inside the killer's mind. And the closest thing to that would be to probe the mind of another killer who is equally brilliant and twisted. For Graham, that means confronting his past and facing his former nemesis, the now-incarcerated Dr. Lecter.

In Italy, a woman fears her sister may have been kidnapped. Inspector Enzo Avolfi fears it's worse. They team up to rescue her from a sadistic killer known only as Yellow.

Successful writer and scholar Jonathan Merrick falls under the spell of the irresistible, bewitchingly beautiful Ligeia. She's fighting a fatal illness and she will stop at nothing to defeat death, her one true enemy. She steals other people's souls and on her quest to immortality she tricks Jonathan into supporting her work, breaking him apart from his fiancé Rowena and pulling him into her dark, mysterious world. They settle down in an old manor by the Black Sea where Ligeia's everlasting presence slowly drives Jonathan to madness...

An American nurse living and working in Tokyo is exposed to a mysterious supernatural curse, one that locks a person in a powerful rage before claiming their life and spreading to another victim.