Alice, now in hiding in the Nevada desert, once again joins forces with Carlos Olivera and L.J., along with new survivors Claire, K-Mart and Nurse Betty to try to eliminate the deadly virus that threatens to make every human being undead...and to seek justice. Since being captured by the Umbrella Corporation, Alice has been subjected to biogenic experimentation and becomes genetically altered, with super-human strengths, senses and dexterity. These skills, and more, will be needed if anyone is to remain alive.
Paranormal researcher Mary Florescu’s (Ward) investigations lead her to Simon McNeal (Armstrong), a college student who appears to be channeling messages from the dead. As their erotic relationship develops, the line between the worlds of the living and the dead become blurred and finally collapse in a stunning and astonishing climax.
Six unsuspecting college co-eds discover their dorm was once the site of a notorious insane asylum infamous for conducting gruesome lobotomy's on its teenage inmates during the 1930's. When the dorm begins to echo scenes from its torture chamber past, the beautiful heroine questions her sanity and if she will make it out alive.