In Europe, a group of American college athletes unknowingly board a train that will become one deadly ride.

Surrounded by carnage, slaughter, brutal crashes and total mayhem, Shawn Black is in a race to save the world from pure evil.

Six months after the rage virus was inflicted on the population of Great Britain, the US Army helps to secure a small area of London for the survivors to repopulate and start again. But not everything goes to plan.

A Birmingham-based band are ordered by their unhappy record company to an old warehouse; the goal being to re-start their ailing careers with a kick-ass new promo video. Unfortunately the band and their entourage find themselves targets of a mysterious knife-wielding maniac, haunted by the voice of Satan, and out for revenge.